Psychotropic dose equivalence in Japan

Table 1 Dose equivalence of antipsychotics
Table 2 Dose equivalence of short-acting injectable antipsychotics
Table 3 Dose equivalence of long-acting injectable antipsychotics
Table 4 Dose equivalence of antiparkinsonian drugs
Table 5 Dose equivalence of antidepressants
Table 6 Dose equivalence of anxiolytics, sedatives and hypnotics

Table 1 Dose equivalence of antipsychotics^†

Aripiprazole	4
Blonanserin	4
Bromperidol	2
Carpipramine^‡	100
Chlorpromazine	100
Clocapramine	40
Clotiapine^‡	40
Clozapine	50
Fluphenazine	2
Haloperidol	2
Levomepromazine	100
Moperone	12.5
Mosapramine	33
Nemonapride	4.5
Olanzapine	2.5
Oxypertine	80
Paliperidone	1.5
Perazine^‡	100

Perospirone	8
Perphenazine	10
Pimozide	4
Pipamperone	200
Prochlorperazine	15
Propericiazine	20
Quetiapine	66
Reserpine	0.15
risperidone	1
Spiperone	1
Sulpiride	200
Sultopride	200
Thioridazine^‡	100
Tiapride	100
Timiperone	1.3
Thiothixene^‡	3.3
Trifluoperazine^‡	5
Zotepine	66

^†Adapted from the previous publications.^5–15
Reproduced with permission. ©Ataru Inagaki & Toshiya Inada.
^‡No longer available in Japan.

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Table 2 Dose equivalence of short-acting injectable antipsychotics

Based on oral chlorpromazine 100 mg (p.o.)

Injectable antipsychotics	Equivalent dose of 100 mg chlorpromazine (p.o.) (mg)
Chlorpromazine (p.o.)	100
Haloperidol (i.m./i.v.)	1
Chlorpromazine (i.m.)	33
Levomepromazine (i.m.)	25
Sulpiride (i.m.)	50
Perphenazine (i.m.)	2
Prochlorperazine (i.m.)	2.14
Timiperone (i.m./i.v.)	0.19
Olanzapine (i.m.)	2.25

Based on the same oral agent (p.o.)

Injectable antipsychotics	(mg)	Equivalent dose of oral administration	(mg)
Haloperidol (i.m./i.v.)	5	Haloperidol (p.o.)	10
Chlorpromazine (i.m.)	50	Chlorpromazine (p.o.)	150
Levomepromazine (i.m.)	25	Levomepromazine (p.o.)	100
Sulpiride (i.m.)	50	Sulpiride (p.o.)	200
Perphenazine (i.m.)	2	Perphenazine (p.o.)	10
Prochlorperazine (i.m.)	5	Prochlorperazine (p.o.)	35
Timiperone (i.m./i.v.)	4	Timiperone (p.o.)	28
Olanzapine (i.m.)	9	Olanzapine (p.o.)	10

Adapted from the previous publication²⁸ and the booklet ‘2014 Year Edition of Drug Directory for Neuropsychiatric Diseases’ (not for sale) designed by the Mitsubishi Tanabe Pharma Corporation (Osaka) and the Yoshitomiyakuhin Corporation (Osaka), published by the Seiwa Shoten Publishers Inc. (Tokyo) in 2014.
Reproduced with permission. ©Ataru Inagaki & Toshiya Inada.
i.m., intramuscular injection; i.v., intravenous injection; p.o., oral administration (per os).

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Table 3 Dose equivalence of long-acting injectable antipsychotics^†

Oral antipsychotics		Long-acting antipsychotics
Chlorpromazine	100 mg/day
Haloperidol	2 mg/day	HP-D	30 mg/4 weeks
Fluphenazine	2 mg/day	FE^‡	7.5 mg/2 weeks
		FD	15 mg/4 weeks
Risperidone	1 mg/day	RLAI	10 mg/2 weeks
Paliperidone	1.5 mg/day	PAL-P	18.75 mg/4 weeks

^†Adapted from the previous publications^13,29–31 and the booklet ‘2014 Year Edition of Drug Directory for Neuropsychiatric Diseases’ (not for sale) designed by the Mitsubishi Tanabe Pharma Corporation (Osaka) and the Yoshitomiyakuhin Corporation (Osaka), published by the Seiwa Shoten Publishers Inc. (Tokyo) in 2014.
Reproduced with permission. ©Ataru Inagaki & Toshiya Inada.
^‡No longer available in Japan.
FD, fluphenazine decanoate; FE, fluphenazine enanthate; HP-D, haloperidol decanoate; PAL-P, paliperidone palmitate; RLAI, risperidone long-acting injection.

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Table 4 Dose equivalence of antiparkinsonian drugs^†

Amantadine	100
Benztropine^‡	1
Biperiden	2
Diphenhydramine	30
Hydroxyzine	65
Mazaticol	8

Metixene^‡	10
Piroheptine	4
Profenamine	100
Promethazine	50
Trihexyphenidyl	4

^†Adapted from the previous publications.^32,33
Reproduced with permission. ©Ataru Inagaki & Toshiya Inada.
^‡No longer available in Japan.

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Table 5 Dose equivalence of antidepressants^†

Amitriptyline	150
Amoxapine	150
Clomipramine	120
Desipramine^‡	150
Dosulepin	150
Duloxetine	30
Escitalopram	20
Fluvoxamine	150
Imipramine	150
Lofepramine	150
Maprotiline	150
Mianserin	60

Milnacipran	100
Mirtazapine	30
Nortriptyline	75
Paroxetine	40
Paroxetine CR	50
Safrazine^‡	30
Sertraline	100
Setiptiline	6
Sulpiride	300
Trazodone	300
Trimipramine	150

^†Adapted from the previous publications^13,38–40 and the booklet ‘2014 Year Edition of Drug Directory for Neuropsychiatric Diseases’ (not for sale) designed by the Mitsubishi Tanabe Pharma Corporation (Osaka) and the Yoshitomiyakuhin Corporation (Osaka), published by the Seiwa Shoten Publishers Inc. (Tokyo) in 2014.
Reproduced with permission. ©Ataru Inagaki & Toshiya Inada.
^‡No longer available in Japan.

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Table 6 Dose equivalence of anxiolytics, sedatives and hypnotics^†

Alprazolam	0.8
Bromazepam	2.5
Chlordiazepoxide	10
Clobazam	10
Clonazepam	0.25
Clorazepate	7.5
Clotiazepam	10
Cloxazolam	1.5
Diazepam	5
Etizolam	1.5
Fludiazepam	0.5
Flutazolam	15
Flutoprazepam	1.67
Loflazepate	1.67
Lorazepam	1.2
Medazepam	10
Mexazolam	1.67
Oxazepam^‡	15
Oxazolam	20
Prazepam^‡	12.5
Tandospirone	25
Tofisopam	125

Amobarbital	50
Barbital	75
Bromvalerylurea	500
Brotizolam	0.25
Butoctamide^‡	500
Chloral hydrate	250
Estazolam	2
Eszopiclone	2.5
Flunitrazepam	1
Flurazepam	15
Haloxazolam	5
Lormetazepam	1
Nimetazepam	5
Nitrazepam	5
Passiflora extract	100
Pentobarbital	50
Phenobarbital	15
Quazepam	15
Rilmazafone	2
Secobarbital	50
Triazolam	0.25
Zolpidem	10
Zopiclone	7.5

^†Adapted from the previous publications.^13,43–45
Reproduced with permission. ©Ataru Inagaki & Toshiya Inada.
^‡No longer available in Japan.

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Psychotropic dose equivalence in Japan

Table 1 Dose equivalence of antipsychotics†

Table 2 Dose equivalence of short-acting injectable antipsychotics

Based on oral chlorpromazine 100 mg (p.o.)

Based on the same oral agent (p.o.)

Table 3 Dose equivalence of long-acting injectable antipsychotics†

Table 4 Dose equivalence of antiparkinsonian drugs†

Table 5 Dose equivalence of antidepressants†

Table 6 Dose equivalence of anxiolytics, sedatives and hypnotics†

Table 1 Dose equivalence of antipsychotics^†

Table 3 Dose equivalence of long-acting injectable antipsychotics^†

Table 4 Dose equivalence of antiparkinsonian drugs^†

Table 5 Dose equivalence of antidepressants^†

Table 6 Dose equivalence of anxiolytics, sedatives and hypnotics^†